Support:+1 929 202 3014


Virus-like Particle (VLP) Antigen Production Service

  • Overview
  • Service Details
  • Service Highlights
  • Related Services
  • Case Study
  • How to order
  • Overview

    Service Number£şABL031

    Virus-like particles (VLPs) are non-infectious virus-derived structures made up of one or more different molecules with the ability to self-assemble, mimicking the form and size of a virus particle but lacking the genetic material. Like native viruses, specific epitopes displayed on VLPs can be taken up, processed, and presented by antigen-presenting cells to elicit potent specific humoral and cell-mediated immune responses. Therefore, VLPs is highly immunogenic and can induce humoral and cellular immune responses, and chimeric VLPs is used as a therapeutic vaccine. 

    The nanosized VLPs traffic through lymph nodes and are taken up by antigen-presenting cells (APCs). VLPs display diverse antigenic epitopes and induce both humoral and cellular anti-viral immune responses. Another advantage of VLPs is that it can be modified to display immunostimulatory cytokines as adjuvants to enhance the vaccine efficacy. These features suggest that VLPs can be used as a potent vaccine platform to develop. As an efficient vehicle, VLPs can deliver drugs to the targeted tissue for treatment or diagnostics. Thus, VLPs production is even more meaningful.

    Abvigen offers the off shelf VLP productions and services to customize VLP generation and package the VLPs to mature ELISA kit, test standard reagent, and relevant products. Our experienced scientists have created a comprehensive platform to generate VLPs for  both academic and industries.

    Service Details





    Pool of 3 plasmids

    encoding viral

    structural proteins


    Bacterial Transformation

    Vector construction

    Selection of Tranaformed Cells

    1-2 weeks

    Test Expression


    Determine Solubility


    1-2 weeks

    Scale Up


    Main culture

    1-2 week





    1-2 week




    1-2 week

    Service Highlights

    Non-enveloped: Bud from the host cell without the host cell membrane.

    Enveloped: Bud from the host cell carrying the host cell membrane and containing the viral proteins on the VLP surface.

    Various systems have been utilized in the successful VLP construction, including bacterial, yeast, insect cells, plant and mammalian hosts.

    Effectively express and purify membrane proteins.

    Support a variety of VLP application services, such as cell targeting, biosensor, and chimeric VLP production.

    A series of VLP characterization approaches, such as SRID, HA assay, DLS, and AFFFF-MALS.

    Related Services
    Case Study
    How to order
    Previous: ELISA Kit Development Service Next: None!