Endotoxin-Free Protein Production
Bacterial endotoxins, found in the outer membrane of gram-negative bacteria are members of a class of phospholipids called lipopolysaccharides (LPS). LPS are not exogenous products of gram negative bacteria. The release of LPS from bacteria takes place after death and lysis of the cell. Good examples of pyrogen producing gram- negative bacteria are Escherichia coli, Proteus, Pseudomonas, Enterobacter and Klebsiella.
LPS contamination triggers secretion of pro-inflammatory cytokines, poor cell growth, reduced DNA transfection efficiency, problematic differentiation, cell death, and compromised experimental results. In humans, LPS activates the immune system, resulting in endotoxic shock or even death.
Abvigen has developed endotoxin-free Expression System, which is able to express a wide variety of protein and oligonucleotides as the wild-type counterparts except that they lack endotoxic activity.
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