Please refer to the vial lable for the specific concentration.
Purification:
Protein A/G
Molecular Weight:
22.3 kDa
Immunogen:
SCF
Buffer:
Supplied in PBS
Storage:
Short Term: 2-8 degree. Long Term: -20 degree. Avoid multiple freeze-thaw cycles.
General Information
Background:
SCF(Stem cell factor) also known as mast cell growth factorang kit ligand, is a hematopoietic growth factor. It plays an role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis. SCF is expressed in where hematopoiesis takes place, such as the fetal liver and bone marrow. SCF binding to c-kit ligand(CD117)causes the receptor to homodimerize and auto-phosphorylate at tyrosine residues. SCF and c-kit ligand are up-regulated in human malignancies including gastrointestinal stromal tumor, breast cancer, hematopoietic cell, myeloid leukaemia, and glioma. The SCF/c-kit pathway also plays a rolein the regulation of cell survival and proliferation, stem cell maintenance, mast cell development, migration.SCF and c-kit were confirmed as key role in hematopoietic function in adult mice.
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