Please refer to the vial lable for the specific concentration.
Purification:
Protein A/G
Molecular Weight:
38.8 kDa
Immunogen:
IL-6R
Buffer:
Supplied in PBS
Storage:
Short Term: 2-8 degree. Long Term: -20 degree. Avoid multiple freeze-thaw cycles.
General Information
Background:
Interleukin-6 (IL-6) is a pleiotropic cytokine produced by a variety of cells during infection, trauma, and immunological challenge. IL-6 acts via a receptor complex consisting of two distinct membrane-bound glycoproteins, an 80-kDa IL-6-binding subunit (IL-6R alpha, CD126, gp80) and a 130-kDa signal-transducing element (gp130, CD130). After binding of IL-6 to membrane-bound IL-6R alpha, the complex of IL-6 and IL-6R alpha associates with gp130, thus activating the receptor. Expression of gp130 is found in almost all organs while expression of IL-6R alpha is predominantly confined to hepatocytes and leukocyte subpopulations (monocytes, neutrophils, T cells, and B cells). Soluble form of IL-6R alpha has been found in human serum and urine.
Synonyms:
CD126, gp80, IL6R, IL-6R alpha, IL-6RA, IL6RQ
Note
For research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals.
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