Please refer to the vial lable for the specific concentration.
Purification:
Protein A/G
Molecular Weight:
58.8 kDa
Immunogen:
PDGFR beta
Buffer:
Supplied in PBS
Storage:
Short Term: 2-8 degree. Long Term: -20 degree. Avoid multiple freeze-thaw cycles.
General Information
Background:
Multiple receptor tyrosine kinases and their growth factor ligands have been implicated in cancer progression and metastasis. Among these are the platelet-derived growth factor receptors (PDGFRs). Expression of PDGFRs is mainly restricted to mesenchymal cell types. PDGF is composed of homo-dimers or hetero-dimers of two polypeptide chains, denoted A and B. The two receptor subtypes show different affinities for the dimeric PDGF isoforms. In epithelial tumors, the platelet-derived growth factor receptor B (PDGFRB, also known as PDGFR beta) is mainly expressed by stromal cells of mesenchymal origin. it has also been shown that PDGFRB is also associated with the aggressive behavior of several types of tumors. The 60% of colon cancer patients express high levels of this gene and the PDGFRB expression correlates with lymphatic dissemination of this cancer. Furthermore, PDGFRB signaling in mesenchymal-like tumor cells (as colorectal cancer cells) contributes to invasion and liver metastasis formation.
Synonyms:
CD140B, JTK12, PDGF R beta, PDGFR, PDGFR beta, PDGFR1, PDGFRB
Note
For research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals.
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