Please refer to the vial lable for the specific concentration.
Purification:
Protein A/G
Molecular Weight:
18.6 kDa
Immunogen:
PD-1
Buffer:
Supplied in PBS
Storage:
Short Term: 2-8 degree. Long Term: -20 degree. Avoid multiple freeze-thaw cycles.
General Information
Background:
Programmed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM). PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function. It is critical for the regulation of T-cell function during immunity and tolerance. Blockade of the PD-1/PD-L1 pathway has been developed for cancer immunotherapy.
Synonyms:
CD279, PD1, PD-1, PDCD1, SLEB2
Note
For research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals.
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