Please refer to the vial lable for the specific concentration.
Purification:
Protein A/G
Molecular Weight:
42.1 kDa
Immunogen:
ICOS
Buffer:
Supplied in PBS
Storage:
Short Term: 2-8 degree. Long Term: -20 degree. Avoid multiple freeze-thaw cycles.
General Information
Background:
Inducible T-cell costimulator (ICOS) is an activation-dependent, T cell-specific cell surface molecule related to CD28 and CTLA-4. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. ICOS has to be de novo induced on the T-cell surface, does not upregulate the production of interleukin-2, but superinduces the synthesis of interleukin-10, a B-cell-differentiation factor. ICOS activated T-cells, Highly expressed on tonsillar T-cells, are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. It is expressed at lower levels in thymus, lung, lymph node, and peripheral blood leukocytes. It is also expressed in the medulla of the fetal and newborn thymus.
Synonyms:
AILIM, CD278, CVID1, ICOS, Inducible T cell costimulator
Note
For research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals.
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