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Rabbit Anti-AXIN1 PAb

Product Description

  • Type:
  • Polyclonal Antibody
  • Source:
  • Rabbit
  • Species:
  • Human
  • Application:
  • ELISA; IHC
  • Description:
  • Swissprot O15169; Gene Accession NP_003493
  • Format:
  • Liquid
  • Concentration:
  • Please refer to the vial lable for the specific concentration.
  • Purification:
  • Protein A/G
  • Buffer:
  • Supplied in PBS.
  • Storage:
  • Short Term: 2-8 degree. Long Term: -20 degree. Avoid multiple freeze-thaw cycles.

General Information

  • Background:
  • This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene.
  • Synonyms:
  • axin 1; AXIN; PPP1R49

Documents

Order Details

Cat No:ABSPA-0938

Conjugate:ABSPA-0938

Size:1 mg

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  • info@abvigenus.com